New Treatment for Post Herpetic Neuralgia
No one who has ever had PHN want this for their worst enemy: it can be that painful.
The below study from Korea shows Ketamin and Magnesium Sulfate helps with pain scores.
The below study from Korea shows Ketamin and Magnesium Sulfate helps with pain scores.
This is an intense protocol for pain management given the way drugs are administered.
Ketamine hydrochloride (Ketara, Parke Davis) or magnesium sulfate (Magnesin) was administered in a double-blind fashion with respect to the assessor and patient. They were given midazolam intravenously (0.1 mg/kg) to render them unconscious. Ketamine (1 mg/kg per hour) and magnesium sulfate (30 mg/kg per hour) were diluted in 0.9% normal saline to a final volume of 100 mL and infused by syringe pump over 1 hour. The drugs were administered on 3 sessions: and each session was performed consecutively every other day. At each of the 3 time points, an electrocardiogram was obtained, and heart rate, noninvasive blood pressure, and pulse oximetry were monitored throughout the drug infusions. Serum magnesium concentrations were measured before the study and at its conclusion and were within normal limits in all patients.
J Clin Anesth. 2015 Mar 17. pii: S0952-8180(15)00053-7. doi: 10.1016/j.jclinane.2015.02.006. [Epub ahead of print]
Is magnesium sulfate effective for pain in chronic postherpetic neuralgia patients comparing with ketamine infusion therapy?
Author information
- 1Department of Anesthesia and Pain Medicine, National Cancer Center, Goyang, Republic of Korea.
- 2Department of Anesthesia and Pain Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea. Electronic address: painsnu@gmail.com.
Abstract
BACKGROUND:
METHOD:
RESULTS:
CONCLUSIONS:
Copyright © 2015. Published by Elsevier Inc.
KEYWORDS:
Ketamine; Magnesium; Postherpetic neuralgia
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